Leigh A Stoddart: search on Z-Library

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1

Design and Elaboration of a Tractable Tricyclic Scaffold To Synthesize Druglike Inhibitors of Dipeptidyl Peptidase-4 (DPP-4), Antagonists of the C–C Chemokine Receptor Type 5 (CCR5), and Highly Potent and Selective Phosphoinositol-3 Kinase δ (PI3Kδ) Inhibitors

Schwehm, Carolin, Kellam, Barrie, Garces, Aimie E., Hill, Stephen J., Kindon, Nicholas D., Bradshaw, Tracey D., Li, Jin, Macdonald, Simon J. F., Rowedder, James E., Stoddart, Leigh A., Stocks, Michael

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 3.06 MB

english, 2017

2

NanoBRET Approaches to Study Ligand Binding to GPCRs and RTKs

Stoddart, Leigh A., Kilpatrick, Laura E., Hill, Stephen J.

Journal:

Trends in Pharmacological Sciences

Year:

2017

Language:

english

File:

PDF, 2.10 MB

english, 2017

3

Development of novel fluorescent histamine H1-receptor antagonists to study ligand-binding kinetics in living cells

Stoddart, Leigh A., Vernall, Andrea J., Bouzo-Lorenzo, Monica, Bosma, Reggie, Kooistra, Albert J., de Graaf, Chris, Vischer, Henry F., Leurs, Rob, Briddon, Stephen J., Kellam, Barrie, Hill, Stephen J.

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 5.22 MB

english, 2018

4

The facile conversion of T-2 toxin and neosolaniol into anguidine

Derek W Anderson, Robin M Black, David A Leigh, J.Fraser Stoddart, Nancy E. Williams

Journal:

Tetrahedron Letters

Year:

1987

Language:

english

File:

PDF, 207 KB

english, 1987

5

Novel 4,15-polyether analogues of macrocyclic trichothecenes

Derek W. Anderson, Robin M. Black, David A. Leigh, J.Fraser Stoddart

Journal:

Tetrahedron Letters

Year:

1987

Language:

english

File:

PDF, 288 KB

english, 1987

6

Novel 3,4- and 8,15-polyether analogues of macrocyclic trichothecenes

Derek W. Anderson, Robin M. Black, David A. Leigh, J.Fraser Stoddart

Journal:

Tetrahedron Letters

Year:

1987

Language:

english

File:

PDF, 248 KB

english, 1987

7

Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3

Graeme Milligan, Leigh A. Stoddart, Nicola J. Smith

Journal:

British Journal of Pharmacology

Year:

2009

Language:

english

File:

PDF, 404 KB

english, 2009

8

G protein-coupled receptors for free fatty acids

Graeme Milligan, Leigh A. Stoddart, Andrew J. Brown

Journal:

Cellular Signalling

Year:

2006

Language:

english

File:

PDF, 158 KB

english, 2006

9

Novel pharmacological applications of G-protein-coupled receptor–G protein fusions

Graeme Milligan, Geraldine Parenty, Leigh A Stoddart, J Robert Lane

Journal:

Current Opinion in Pharmacology

Year:

2007

Language:

english

File:

PDF, 339 KB

english, 2007

10

Fragment Screening at Adenosine-A3 Receptors in Living Cells Using a Fluorescence-Based Binding Assay

Leigh A. Stoddart, Andrea J. Vernall, Jessica L. Denman, Stephen J. Briddon, Barrie Kellam, Stephen J. Hill

Journal:

Chemistry & Biology

Year:

2012

Language:

english

File:

PDF, 1.49 MB

english, 2012

11

Probing Allosteric Binding Site Mapping in the Free Fatty Acid 2 receptor

Tikhonova, Irina G., Smith, Nicola J., Ward, Richard J., Stoddart, Leigh A., Hudson, Brian D., Kostenis, Evi, Ulven, Trond, Morris, Joanne C., Adams, David R., Milligan, Graeme

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 35 KB

english, 2011

12

Highly Potent and Selective Fluorescent Antagonists of the Human Adenosine A 3 Receptor Based on the 1,2,4-Triazolo[4,3- a ]quinoxalin-1-one Scaffold

Vernall, Andrea J., Stoddart, Leigh A., Briddon, Stephen J., Hill, Stephen J., Kellam, Barrie

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 3.83 MB

english, 2012

13

Conversion of a non-selective adenosine receptor antagonist into A3-selective high affinity fluorescent probes using peptide-based linkers

Vernall, Andrea J., Stoddart, Leigh A., Briddon, Stephen J., Ng, Hui Wen, Laughton, Charles A., Doughty, Stephen W., Hill, Stephen J., Kellam, Barrie

Journal:

Organic & Biomolecular Chemistry

Year:

2013

Language:

english

File:

PDF, 1.76 MB

english, 2013

14

The complexation properties of some unnatural and natural macrocyclic trichothecenes

Anderson, Derek W., Ashton, Peter R., Black, Robin M., Leigh, David A., Slawin, Alexandra M. Z., Stoddart, J. Fraser, Williams, David J.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1988

Language:

english

File:

PDF, 481 KB

english, 1988

15

Studying the Diffusion Characteristics of Different Activity States of the Human Adenosine-A3 Receptor Using Fluorescence Correlation Spectroscopy

Corriden, Ross, Stoddart, Leigh, Briddon, Stephen, Hill, Stephen J.

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 94 KB

english, 2010

16

Effect of a toggle switch mutation in TM6 of the human adenosine A 3 receptor on Gi protein-dependent signalling and Gi-independent receptor internalization

Stoddart, Leigh A, Kellam, Barrie, Briddon, Stephen J, Hill, Stephen J

Journal:

British Journal of Pharmacology

Year:

2014

Language:

english

File:

PDF, 1.91 MB

english, 2014

17

Probing the pharmacology of G protein-coupled receptors with fluorescent ligands

Stoddart, Leigh A., Kilpatrick, Laura E., Briddon, Stephen J., Hill, Stephen J.

Journal:

Neuropharmacology

Year:

2015

Language:

english

File:

PDF, 1.61 MB

english, 2015

18

Application of BRET to monitor ligand binding to GPCRs

Stoddart, Leigh A, Johnstone, Elizabeth K M, Wheal, Amanda J, Goulding, Joëlle, Robers, Matthew B, Machleidt, Thomas, Wood, Keith V, Hill, Stephen J, Pfleger, Kevin D G

Journal:

Year:

2015

Language:

english

File:

PDF, 619 KB

english, 2015

19

Fluorescent ligands for G protein-coupled receptors: illuminating receptor–ligand interactions for drug discovery

Stoddart, Leigh A, Briddon, Stephen J, Hill, Stephen J

Journal:

Future Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 883 KB

english, 2013

20

[Methods in Enzymology] Constitutive Activity in Receptors and Other Proteins, Part A Volume 484 || Constitutive Activity of GPR40/FFA1

Stoddart, Leigh A.

Year:

2010

Language:

english

File:

PDF, 296 KB

english, 2010

21

Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist

Stoddart, Leigh A., Vernall, Andrea J., Briddon, Stephen J., Kellam, Barrie, Hill, Stephen J.

Journal:

Neuropharmacology

Year:

2015

Language:

english

File:

PDF, 3.15 MB

english, 2015

22

Fragment-based discovery of subtype selective adenosine receptor ligands from homology models

Ranganathan, Anirudh, Stoddart, Leigh A, Hill, Stephen J, Carlsson, Jens

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 5.83 MB

english, 2015

23

Synthesis, Biological Evaluation and Utility of Fluorescent Ligands Targeting the µ-Opioid Receptor

Schembri, Luke S., Stoddart, Leigh A., Briddon, Stephen J., Kellam, Barrie, Canals, Meritxell, Graham, Bim, Scammells, Peter J.

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.50 MB

english, 2015

24

ChemInform Abstract: Novel 4,15-Polyether Analogues (I) of Macrocyclic Trichothecenes.

ANDERSON, D. W., BLACK, R. M., LEIGH, D. A., STODDART, J. F.

Journal:

Year:

1987

File:

PDF, 97 KB

1987

25

ChemInform Abstract: The Facile Conversion of T-2 Toxin and Neosolaniol into Anguidine.

ANDERSON, D. W., BLACK, R. M., LEIGH, D. A., STODDART, J. F., WILLIAMS, N. E.

Journal:

Year:

1987

File:

PDF, 88 KB

1987

26

ChemInform Abstract: Novel 3,4- and 8,15-Polyether Analogues (I) - (III) of Macrocyclic Trichothecenes.

ANDERSON, D. W., BLACK, R. M., LEIGH, D. A., STODDART, J. F.

Journal:

Year:

1987

File:

PDF, 167 KB

1987

27

Fluorescence- and bioluminescence-based approaches to study GPCR ligand binding

Stoddart, Leigh A, White, Carl W, Nguyen, Kim, Hill, Stephen J, Pfleger, Kevin D G

Journal:

British Journal of Pharmacology

Year:

2015

Language:

english

File:

PDF, 620 KB

english, 2015

28

Use of a new proximity assay (NanoBRET) to investigate the ligand-binding characteristics of three fluorescent ligands to the human β 1 -adrenoceptor expressed in HEK-293 cells

Soave, Mark, Stoddart, Leigh A., Brown, Alastair, Woolard, Jeanette, Hill, Stephen J.

Journal:

Pharmacology Research & Perspectives

Year:

2016

Language:

english

File:

PDF, 561 KB

english, 2016

29

Synthesis and Evaluation of the first Fluorescent Antagonists of the Human P2Y 2 Receptor based on AR-C118925

Conroy, Sean, Kindon, Nicholas D., Glenn, Jacqueline, Stoddart, Leigh A., Lewis, Richard James, Hill, Stephen J., Kellam, Barrie, Stocks, Michael John

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 2.02 MB

english, 2018

30

Correction to Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y 2 Receptor Based on AR-C118925

Conroy, Sean, Kindon, Nicholas D., Glenn, Jacqueline, Stoddart, Leigh A., Lewis, Richard J., Hill, Stephen J., Kellam, Barrie, Stocks, Michael J.

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 203 KB

english, 2018

31

A Non-imaging High Throughput Approach to Chemical Library Screening at the Unmodified Adenosine-A3 Receptor in Living Cells

Arruda, Maria Augusta, Stoddart, Leigh A., Gherbi, Karolina, Briddon, Stephen J., Kellam, Barrie, Hill, Stephen J.

Journal:

Frontiers in Pharmacology

Year:

2017

Language:

english

File:

PDF, 3.43 MB

english, 2017

32

Binding kinetics of ligands acting at GPCRs

Sykes, David A., Stoddart, Leigh A., Kilpatrick, Laura E., Hill, Stephen J.

Journal:

Molecular and Cellular Endocrinology

Year:

2019

Language:

english

File:

PDF, 2.47 MB

english, 2019

33

Probe dependency in the determination of ligand binding kinetics at a prototypical G protein-coupled receptor

Bosma, Reggie, Stoddart, Leigh A., Georgi, Victoria, Bouzo-Lorenzo, Monica, Bushby, Nick, Inkoom, Loretta, Waring, Michael J., Briddon, Stephen J., Vischer, Henry F., Sheppard, Robert J., Fernández-Mo

Journal:

Scientific Reports

Year:

2019

Language:

english

File:

PDF, 3.03 MB

english, 2019

34

Subtype-selective Fluorescent Ligands as Pharmacological Research Tools for the Human Adenosine A2A Receptor

Comeo, Eleonora, Kindon, Nicholas D., Soave, Mark, Stoddart, Leigh A., Kilpatrick, Laura, Scammells, Peter J., Hill, Stephen John, Kellam, Barrie

Journal:

Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 2.23 MB

english, 2019

35

Subtype-selective Fluorescent Ligands as Pharmacological Research Tools for the Human Adenosine A2A Receptor

Comeo, Eleonora, Kindon, Nicholas D., Soave, Mark, Stoddart, Leigh A., Kilpatrick, Laura, Scammells, Peter J., Hill, Stephen John, Kellam, Barrie

Journal:

Journal of Medicinal Chemistry

Year:

2019

File:

PDF, 2.23 MB

2019

36

Fluorescent ligands: Bringing light to emerging G protein‐coupled receptor paradigms

Soave, Mark, Briddon, Stephen J., Hill, Stephen J., Stoddart, Leigh A.

Journal:

British Journal of Pharmacology

Year:

2019

File:

PDF, 1.61 MB

2019

37

Single molecule binding of a ligand to a G-protein-coupled receptor in real time using fluorescence correlation spectroscopy, rendered possible by nano-encapsulation in styrene maleic acid lipid particles

Grime, Rachael L., Goulding, Joelle, Uddin, Romez, Stoddart, Leigh A., Hill, Stephen J., Poyner, David R., Briddon, Stephen J., Wheatley, Mark

Journal:

Year:

2020

File:

PDF, 1.29 MB

2020

38

Ligand-directed covalent labelling of a GPCR with a fluorescent tag in live cells

Stoddart, Leigh A., Kindon, Nicholas D., Otun, Omolade, Harwood, Clare R., Patera, Foteini, Veprintsev, Dmitry B., Woolard, Jeanette, Briddon, Stephen J., Franks, Hester A., Hill, Stephen J., Kellam,

Journal:

Communications Biology

Year:

2020

File:

PDF, 1.49 MB

2020

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